Search results for " BAX"
showing 4 items of 4 documents
Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells.
2011
SUMMARYAlthough many cancer cells are primed for apoptosis, they usually develop resistance to cell death at multiple levels. Permeabilization of the outer mitochondrial membrane, which is mediated by proapoptotic Bcl-2 family members like Bax, is considered as a point-of-no-return for initiating apoptotic cell death. This crucial role has placed Bcl-2 family proteins as recurrent targets for anticancer drug development. Here, we propose and demonstrate a new concept based on using minimal active version of Bax to induce cell death independently of endogenous Bcl-2 proteins. We show that membrane-active segments of Bax can directly induce the release of mitochondria-residing apoptogenic fac…
L'ANTICO CAMPANILE DELLA CATTEDRALE DI LECCE IN UN CONSULTO DEL 1574
2016
L'antico campanile della cattedrale di Lecce si trovava in una posizione diversa rispetto a quello esistente costruito nel 1658. La maestosa torre, con cinque ordini e una terminazione a corona, era collocata di fianco all'antica facciata principale della chiesa, sul lato sinistro. Nel 1574 a causa di numerosi crolli, gli amministratori della chiesa decisero di avvalersi del parere tecnico di tre professionisti: Padoano Schiero, Padoano Baxi e Gabriele Meschinello, chiamati ad esprimersi in merito alla pericolosità di tali crolli e allo stato della torre. Vennero prodotte tre relazioni tecniche i cui contenuti illustravano la necessità di demolire la torre al fine di scongiurare eventuali d…
Prognostic Value of p53, p21/WAF1, Bcl-2, Bax, Bak and Ki-67 Immunoreactivity in pT1 G3 Urothelial Bladder Carcinomas
2001
pT1 G3 bladder carcinomas are heterogeneous with respect to tumor recurrence and progression. Whereas some urologists treat these carcinomas by repeated transurethral resections often followed by intravesical chemotherapy or BCG instillation, others recommend cystectomy after tumor recurrence or early cystectomy after the initial diagnosis. Our goal was to determine the prognostic value of p53, p21/WAF1, Bcl-2, Bax, Bak, and Ki-67 immunoreactivity in these tumors. There were 30 patients with a new histopathological diagnosis of pT1 G3 urothelial carcinoma based on a transurethral resection specimen. Representative sections of these specimens were examined for the above markers. All patients…